PREPARATION AND FACILITATION OF ANTIBACTERIAL ACTIVITY, HYDROPHILICITY OF PIEZO–PVDF/n-MgO FILM BY ELECTRO-SPINNING AND SPIN COATED FOR WOUND DRESSING: A COMPARATIVE STUDY
Asra Ali Hussein and Ohood Hmaizah Sabr
Babylon University-College of Materials Engineering, Department of Polymer and Petrochemical Industries
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Antimicrobial resistance of bacteria is one of the serious problems that appears in wound healing and may result in difficulties such as reduction in healing time or inflammations. Piezoelectric materials might be utilized in producing bioactive electrically charged surface. This paper focuses on producing two groups of bio-composite from polyvinylidene fluoride with addition of Nano-magnesium oxide (3, 5 and 7 %) wt. by two methods: electro-spinning and spin coating under special condition, with the aim of producing bio film as sensor for wound healing. The Antibacterial test was illustrated by Agar well dispersion strategy for three groups of the prepared film, reflecting the ability of n-MgO/PVDF biofilm to prevent the bacterial growth. The best sample that showed the greatest inhabitation zone was 7 wt.% n-MgO for both types of bacteria, in contrast with spin coated samples, which did not give any results for both type of bacteria. The AFM revealed topography of nanofiber (PVDF /n-MgO), which appeared like hills as compared to the same sample prepared by spin coating. DSC test showed that the increment of n-MgO to PVDF brought about a diminishing in the enthalpy for fusion (ΔHm), suggesting a reduction in the crystallinity in PVDF. From contact angle test, it can be seen that the pure PVDF nanofiber showed water contact angle (WCA) of ∼108◦, which showed the hydrophobic nature. The WCA is enhanced by presenting MgO and increasing MgO content. The WCA showed enhancement in increasing hydrophilic action where nanofiber (PVDF /n-MgO) showed WCA of 120◦ diminishes to 41◦and the sliding angle diminishes displaying super- hydrophilicity. Consequently, the antibacterial action of the arranged nanofiber tests was improved, when contrasted with the counterpart spin coated membrane. Morphological analysis of first group demonstrated the presentation of random Nano fiber with some agglomeration of nano-MgO, where these agglomerates diffuse through agar plate and cause inhabitation of bacterial growth, while the second group shows smoother and flattened surface topography where the morphology appeared as a ringed-spherulitic matrix. FTIR studies reveal the presence of piezoelectric β–phase at 840cm-1 wave. As a result, the piezoelectric properties are found in the electrospun PVDF/n-MgO nanofiber which is necessary for advancement of biosensors used in sensing wound healing.